![[RDF data]](http://data.linkedct.org/snorql/rdf_flyer.24.gif)
Trial NCT00477789
Resource URI: http://data.linkedct.org/resource/trials/NCT00477789
| Property | Value |
|---|---|
| linkedct:brief_title | Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients |
| linkedct:condition | <http://data.linkedct.org/resource/condition/2728> |
| linkedct:criteria | Inclusion Criteria: - chronic heart failure; - left ventricular systolic dysfunction (ejection fraction <45%) - stable clinical conditions in the previous three months - optimal medical therapy for CHF - normal sinus rhythm - written informed consent - age >18 years Exclusion Criteria: - renal failure (s-creatinine >2.5 mg/dl) - already on allopurinol - malignancies - chronic inflammatory diseases |
| linkedct:download_date | Information obtained from ClinicalTrials.gov on December 30, 2009 |
| linkedct:eligibility_gender | Both |
| linkedct:eligibility_healthy_volunteers | No |
| linkedct:eligibility_maximum_age | N/A |
| linkedct:eligibility_minimum_age | 18 Years |
| linkedct:enrollment | 0 (xsd:int) |
| linkedct:firstreceived_date | May 23, 2007 |
| linkedct:has_dmc | No |
| linkedct:id | NCT00477789 |
| rdfs:label | Trial NCT00477789 |
| linkedct:lastchanged_date | May 23, 2007 |
| linkedct:lead_sponsor_agency | <http://data.linkedct.org/resource/agency/2845> |
| linkedct:location | <http://data.linkedct.org/resource/location/80182> |
| linkedct:nct_id | NCT00477789 |
| linkedct:number_of_arms | 2 (xsd:int) |
| linkedct:number_of_groups | 0 (xsd:int) |
| linkedct:official_title | Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients |
| linkedct:org_study_id | 802 |
| linkedct:overall_official | <http://data.linkedct.org/resource/overall_official/37670> |
| linkedct:overall_status | Completed |
| linkedct:oversight | <http://data.linkedct.org/resource/oversight/1550> |
| foaf:page | <http://clinicaltrials.gov/show/NCT00477789> |
| linkedct:phase | Phase 4 |
| linkedct:primary_outcomes | <http://data.linkedct.org/resource/primary_outcomes/73660> |
| linkedct:source | Universita di Verona |
| linkedct:study_design | Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study |
| linkedct:study_type | Interventional |
| linkedct:summary | In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase with allopurinol might affect diastolic function in patients with CHF. |
| rdf:type | linkedct:trials |
| linkedct:verification_date | May 2007 |
